囊泡乙酰胆碱通道抗体
规格：1mg/1ml
英文名： Vesicular Acetylcholine Transporter
别名： Vesicular Acetylcholine Transporter; MGC12716; rVAT; SLC18A3; Solute carrier family 18 (vesicular acetylcholine) member 3; Solute carrier family 18 (vesicular monoamine) member 3; Solute carrier famil
分子量： 57kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human VAT
交叉反应：Human, Mouse, Rat, Rabbit,
细胞定位：细胞膜
囊泡乙酰胆碱通道抗体产品介绍：background: Vesicular Acetylcholine Transporter (VAChT), (~70kD protein), belongs to the family of vesicular monoamine transporters(VMATs), which include VMAT1 and VMAT2 and the C.elegans putative ACh transporter unc-17. Members of this family function to concentrate neurotransmitters into synaptic vesicles through exchange of protons for neurotransmitters. VAChT is a functional transporter for the neurotransmitter acetylcholine(ACh). ACh is synthesized in the cytoplasm by choline acetyl transferase (ChAT) and transported by VAChT into synaptic vesicles where it is stored until released. After release from presynaptic nerve terminals ACh is hydrolyzed by extracellular ACh-esterases(AChE) to choline and acetate. VAChT mRNA is expressed in all known major cholinergic neurons in the central囊泡乙酰胆碱通道抗体 and peripheral nervous system. VAChT is abundantly expressed in the CNS and is mainly localized in small synaptic vesicles in cholinergic nerve terminals. VAChT provides a specific marker for cholinergic neurons for the study of cholinergic transmission in experimental models, in Alzheimer’s disease and other nervous system disorders. Function: Involved in acetylcholine transport into synaptic vesicles. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Peripheral and central cholinergic nervous systems. Similarity: Belongs to 囊泡乙酰胆碱通道抗体the major facilitator superfamily. Vesicular transporter family. Gene ID: 6572 Database links: Entrez Gene: 6572 Human Entrez Gene: 20508 Mouse Entrez Gene: 60422 Rat Omim: 600336 Human SwissProt: Q16572 Human SwissProt: O35304 Mouse SwissProt: Q62666 Rat Unigene: 654374 Human Unigene: 190503 Mouse Unigene: 9987 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产囊泡乙酰胆碱通道抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 细胞生物 **学 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid