硫辛酰连接酶2抗体
规格：1mg/1ml
英文名： LIPT2
别名： EC 2.3.1.181; FCT2; Lipoate-protein ligase B; Lipoyl(octanoyl) transferase 2 (putative); Lipoyl/octanoyl transferase; Lipt2; LIPT2_HUMAN; mitochondrial; Octanoyl-[acyl-carrier-protein]-protein N-octan
分子量： 23kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human LIPT2
交叉反应：Human, Mouse, Rat, Dog, Horse,
细胞定位：
硫辛酰连接酶2抗体产品介绍：background: LIPT2 is a 231 amino acid mitochondrial protein that belongs to the LipB family. LIPT2 catalyzes the exchange of octanoic acid from octanoyl-acyl-carrier-protein to lipoate-dependent enzymes. The gene encoding LIPT2 maps to human chromosome 11, which comprises approximately 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and thalassemia are caused by HBB gene mutations, while Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell 硫辛酰连接酶2抗体and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11-encoded genes. Function: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although 硫辛酰连接酶2抗体octanoyl-ACP is likely to be the physiological substrate. Subcellular Location: Mitochondrion. Similarity: Belongs to the lipB family. Gene ID: 387787 Database links: Entrez Gene: 387787 Human Entrez Gene: 67164 Mouse Entrez Gene: 365314 Rat SwissProt: A6NK58 Human SwissProt: Q9D009 Mouse Unigene: 591971 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
硫辛酰连接酶2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导 新陈代谢 线粒体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid