LIN7B蛋白抗体
规格：1mg/1ml
英文名： LIN7B
别名： hVeli2; hLin7B; hVeli2; Lin 7 homolog B C elegans; LIN 7B; Lin 7b protein likely ortholog of mouse LIN 7B mammalian LIN 7 protein 2; Lin-7B; LIN7B; LIN7B_HUMAN; MALS 2; MALS-2; MALS2; Mammalian lin se
分子量： 23kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human LIN7B
交叉反应：Human, Mouse, Rat, Pig, Horse,
细胞定位：细胞膜
LIN7B蛋白抗体产品介绍：background: Velis are a family of small synaptic proteins that interact with other proteins at the post-synaptic density (PSD) of neuronal synapses. Velis contain the PDZ motif involved in recruiting cell adhesion molecules, receptors, and channels. Veli1 (also designated Lin-7-B and MALS-1), Veli2 (also designated Lin-7A and MALS-2), and Veli3 (also designated Lin-7C and MALS-3) are mammalian homologs of C. elegans LIN-7. Veli proteins are ubiquitously expressed with high expression in brain, liver, and testis. Velis are localized at the synaptic junctions in neurons. Velis bind to CASK, a neurexin-binding protein highly concentrated in synapses, and Mint1, a binding partner with a vesicle trafficking protein. Function: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct LIN7B蛋白抗体membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ACCN3 acid-evoked currents by stabilizing the channel at the cell surface. Subcellular Location: Cell membrane. Basolateral cell membrane. Cell junction. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell junction > tight junction. Cell junction > LIN7B蛋白抗体synapse > synaptosome. Enriched in synaptosomes and at epithelial cell-cell junctions (By similarity). Mainly basolateral in renal epithelial cells. Similarity: Belongs to the lin-7 family. Contains 1 L27 domain. Contains 1 PDZ (DHR) domain. Gene ID: 64130 Database links: Entrez Gene: 616283 Cow Entrez Gene: 64130 Human Entrez Gene: 22342 Mouse Entrez Gene: 60377 Rat Omim: 612331 Human SwissProt: Q2KIB6 Cow SwissProt: Q9HAP6 Human SwissProt: O88951 Mouse SwissProt: Q9Z252 Rat Unigene: 221737 Human Unigene: 20472 Mouse Unigene: 44184 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
LIN7B蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 神经生物学 信号转导 细胞粘附分子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid