LCK相互作用膜蛋白抗体
规格：1mg/1ml
英文名： LIME
别名： dJ583P15.4; FLJ20406; LIME1_HUMAN; Lck interacting membrane protein; Lck interacting molecule; Lck interacting transmembrane adaptor 1; LIME 1; LIME1; LP8067; RP4 583P15.5.
分子量： 32kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human LIME
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow, Horse,
细胞定位：细胞膜
LCK相互作用膜蛋白抗体产品介绍：background: LIME1 is a raft-associated transmembrane adaptor phosphoprotein that is preferentially expressed in hemopoietic cells, particularly T cells (Brdickova et al., 2003 [PubMed 14610046]; Hur et al., 2003 [PubMed 14610044]).[supplied by OMIM, Mar 2008] Function: LIME (Lck-interacting molecule) is a new raft-associated adaptor protein involved in regulation of T cell activation by coreceptors. LIME becomes tyrosine phosphorylated after cross-linking of the CD4 or CD8 coreceptors. Phospho-LIME associates with the Src family kinase Lck and its negative regulator, Csk. Ectopic expression of LIME in Jurkat T LCK相互作用膜蛋白抗体cells results in an increase of Csk in lipid rafts,LCK相互作用膜蛋白抗体 increased phosphorylation of Lck and higher Ca2+ response to CD3 stimulation. Subcellular Location: Cell membrane; Single-pass type III membrane protein. Present in lipid rafts. Recruited to the immunological synapse upon conjugation of T cell with antigen presenting cell Gene ID: 54923 Database links: Entrez Gene: 54923 Human Omim: 609809 Human SwissProt: Q9H400 Human Unigene: 233220 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
LCK相互作用膜蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 t-**细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid