巨噬细胞炎性蛋白3样蛋白1抗体
规格：1mg/1ml
英文名： LD78 beta/CCL3L1
别名： 464.2; C C motif chemokine 3 like 1; CCL3L1; CCL3L3; Chemokine (C C motif) ligand 3 like 1; Chemokine (C C motif) ligand 3 like 3; Chemokine (C C motif) ligand 3 like, centromeric; chemokine (CC motif
分子量： 8kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human LD78 bet
交叉反应：Human, Recombinant Fragment
细胞定位：分泌型蛋白
巨噬细胞炎性蛋白3样蛋白1抗体产品介绍：background: This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility.[provided by RefSeq, Apr 2014] Function: Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold 巨噬细胞炎性蛋白3样蛋白1抗体higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5. Subcellular Location: Secreted. Post-translational modifications: The N-terminal processed forms LD78-beta(3-70) and LD78-beta(5-70) are produced by proteolytic cleavage after secretion from peripheral blood monocytes. The cleavage to yield LD78-beta(3-70) is probably 巨噬细胞炎性蛋白3样蛋白1抗体achieved by DPP4. Similarity: Belongs to the intercrine beta (chemokine CC) family. Gene ID: 414062 Database links: Entrez Gene: 414062 Human Entrez Gene: 6349 Human Omim: 601395 Human Omim: 609468 Human SwissProt: P16619 Human Unigene: 512304 Human Unigene: 512683 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
巨噬细胞炎性蛋白3样蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid