交叉蛋白1抗体
规格：1mg/1ml
英文名： Intersectin 1
别名： Human intersectin SH3 domain containing protein SH3P17; Intersectin 1 SH3 domain protein; intersectin 1 short form variant 3; intersectin 1 short form variant, 11; Intersectin short form; intersectin
分子量： 195kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Intersec
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞膜
交叉蛋白1抗体产品介绍：background: The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far. [provided by RefSeq, Jul 2008] Function: Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated 交叉蛋白1抗体vesicles. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1. Subcellular Location: Endomembrane system. Cell junction > synapse > synaptosome. Cell projection > lamellipodium. Tissue Specificity: Isoform 2 is ubiquitous in ***** and fetal tissues with high expression in skeletal muscle, heart, spleen, ovary, testis and all fetal tissues tested and low expression in thymus, blood, lung, liver and pancreas. Isoform 1 is expressed almost exclusively in the brain, in all brain regions. Not expressed in the spinal cord. Similarity: Contains交叉蛋白1抗体 1 C2 domain. Contains 1 DH (DBL-homology) domain. Contains 2 EF-hand domains. Contains 2 EH domains. Contains 1 PH domain. Contains 5 SH3 domains. Gene ID: 602442 Database links: Entrez Gene: 6453 Human Entrez Gene: 16443 Mouse Entrez Gene: 29491 Rat Omim: 602442 Human SwissProt: Q15811 Human SwissProt: Q9Z0R4 Mouse SwissProt: Q9WVE9 Rat Unigene: 160324 Human Unigene: 40546 Mouse Unigene: 48657 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
交叉蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid