白细胞介素23P19抗体
规格：1mg/1ml
英文名： IL23 P19
别名： alpha subunit P19; IL-23 subunit alpha; IL-23-A; IL-23p19; IL23; IL23 P 19; IL23A; IL23A_HUMAN; IL23P19; interleukin 23 alpha subunit p19; interleukin 23 P19 subunit; Interleukin-23 subunit alpha; Int
分子量： 19kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human IL23 P19
交叉反应：Human, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：分泌型蛋白
白细胞介素23P19抗体产品介绍：background: This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008] Function: Associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor白细胞介素23P19抗体complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. Subcellular Location: Secreted. Secreted upon association with IL12B. Tissue 白细胞介素23P19抗体Specificity: Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level). Similarity: Belongs to the IL-6 superfamily. Gene ID: 51561 Database links: Entrez Gene: 51561 Human Entrez Gene: 83430 Mouse Entrez Gene: 155140 Rat Omim: 605580 Human SwissProt: Q9NPF7 Human SwissProt: Q9EQ14 Mouse SwissProt: Q91Z84 Rat Unigene: 382212 Human Unigene: 98309 Human Unigene: 125482 Mouse Unigene: 81073 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
白细胞介素23P19抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid