脑蛋白1抗体
规格：1mg/1ml
英文名： HUCE1
别名： Cerebral protein 1; hypothetical protein LOC23378; KIAA0409; Nucleomethylin; Ribosomal RNA processing 8 methyltransferase homolog; Ribosomal RNA processing 8, methyltransferase, homolog (yeast); Ribos
分子量： 51kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HUCE1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞核
脑蛋白1抗体产品介绍：background: Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the 脑蛋白1抗体rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. Subcellular Location: Nucleus > nucleolus. Localizes at rDNA locus. Similarity: Belongs to the methyltransferase superfamily. RRP8 family. Gene ID: 23378 Database links: Entrez Gene: 23378 Human Entrez Gene: 540208 Cow Entrez Gene: 476835 Dog Entrez Gene: 100070052 Horse Entrez Gene: 脑蛋白1抗体101867 Mouse Entrez Gene: 100623550 Pig Entrez Gene: 100355346 Rabbit SwissProt: O43159 Human SwissProt: Q9DB85 Mouse Unigene: 652255 Human Unigene: 231400 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
脑蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid