乳腺癌易感基因复合物HSPC142抗体
规格：1mg/1ml
英文名： HSPC142
别名： BABA1_HUMAN; babam1; BRCA1 A complex subunit MERIT40; BRISC and BRCA1-A complex member 1; C19orf62; FLJ20571; HSPC142; hypothetical protein LOC29086; Mediator of Rap80 interactions and targeting 40 kD
分子量： 36kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HSPC142
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Cat, Chinese Hamster, Orangutan, Elephant
细胞定位：细胞核 细胞浆
乳腺癌易感基因复合物HSPC142抗体产品介绍：background: Consisting of around 63 million bases with over 1,400 genes, chromosome 19 makes up over 2% of human genomic DNA. Chromosome 19 includes a diversity of interesting genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin superfamily members including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family, and Fc?receptors. Key genes for eye color and hair color also map to chromosome 19. Peutz-Jeghers syndrome, spinocerebellar ataxia type 6, the stroke disorder CADASIL, hypercholesterolemia and insulin-dependent diabetes have been linked to chromosome 19. Translocations with chromosome 19 and chromosome 14 can be seen in some lymphoproliferative disorders and typically involve the proto-oncogene BCL3. The C19orf62 gene product has been provisionally designated C19orf62 乳腺癌易感基因复合物HSPC142抗体pending further characterization. Function: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36. component. Subcellular乳腺癌易感基因复合物HSPC142抗体 Location: Cytoplasm. Nucleus. Localizes at sites of DNA damage at double-strand breaks. Similarity: Belongs to the BABAM1 family. Gene ID: 29086 Database links: Entrez Gene: 29086 Human Entrez Gene: 68251 Mouse Entrez Gene: 290631 Rat Omim: 612766 Human SwissProt: Q9NWV8 Human SwissProt: Q3UI43 Mouse SwissProt: Q5XIJ6 Rat Unigene: 190722 Human Unigene: 21749 Mouse Unigene: 74107 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
乳腺癌易感基因复合物HSPC142抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 转录调节因子 糖尿病 表观遗传学
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid