热休克蛋白70结合蛋白1抗体
规格：1mg/1ml
英文名： HspBP1
别名： 1500019G21Rik; FES1; Heat shock protein 70 binding protein; Heat shock protein 70 interacting protein; Heat shock protein binding protein 1; Heat shock protein-binding protein 1; Heat-shock 70-KD prot
分子量： 39kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HspBP1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核 细胞浆
热休克蛋白70结合蛋白1抗体产品介绍：background: Hsp70-interacting protein (HspBP1) belongs to a family of eukaryotic proteins identified as nucleotide exchange factors for Hsp70, which exhibit varying degrees of compartment and species specificity. HspBP1 interferes with the CHIP-induced degradation of immature forms of the cystic fibrosis transmembrane conductance regulator (CFTR) and stimulates CFTR maturation. HspBP1 binds to Hsp70, inhibits its activity and promotes dissociation of nucleotides from the Hsp70 ATPase domain热休克蛋白70结合蛋白1抗体. It is a protein mainly expressed in heart and skeletal muscle. Function: Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR. Tissue Specificity: Ubiquitous. Similarity: Contains 4 ARM repeats.热休克蛋白70结合蛋白1抗体 Gene ID: 23640 Database links: Entrez Gene: 23640 Human Entrez Gene: 66245 Mouse Entrez Gene: 246146 Rat Omim: 612939 Human SwissProt: Q9NZL4 Human SwissProt: Q99P31 Mouse SwissProt: Q6IMX7 Rat Unigene: 53066 Human Unigene: 6803 Mouse Unigene: 4297 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
热休克蛋白70结合蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 结合蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid