组织相容性复合物A2抗体
规格：1mg/1ml
英文名： HLA A2
别名： Antigen presenting molecule; HLA A; HLA A histocompatibility type; HLA; HLA class I; HLA class I histocompatibility antigen A 2 alpha chain; HLA class I histocompatibility antigen A2 alpha chain; HLA-
分子量： 38kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HLA A2
交叉反应：Human,
细胞定位：细胞膜
组织相容性复合物A2抗体产品介绍：background: HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each组织相容性复合物A2抗体 class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008] Function: Involved in the presentation of foreign antigens to the组织相容性复合物A2抗体 immune system. Dimer of alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein. Subcellular Location: Membrane; Single-pass type I membrane protein. Similarity: Belongs to the MHC class I family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain. Gene ID: 3105 Database links: Entrez Gene: 3105 Human Omim: 142800 Human SwissProt: P04439 Human Unigene: 181244 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
组织相容性复合物A2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 细胞膜蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid