高迁移率族蛋白N3抗体
规格：1mg/1ml
英文名： HMGN3
别名： DKFZp686E20226; FLJ42187; High mobility group nucleosomal binding domain 3; High mobility group nucleosome-binding domain-containing protein 3; HMGN3; HMGN3_HUMAN; OTTHUMP00000016772; OTTHUMP000000167
分子量： 11kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HMGN3
交叉反应：Human, Mouse, Rat, Cow, Rabbit,
细胞定位：细胞核
高迁移率族蛋白N3抗体产品介绍：background: Thyroid hormone receptors are hormone-dependent transcription factors that regulate expression of a variety of specific target genes. The protein encoded by this gene binds thyroid hormone receptor beta, but only in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011] Function: Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the高迁移率族蛋白N3抗体 glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function. Subcellular Location: Nucleus. Tissue Specificity: Expressed in kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate and uterus. Low expression in liver, spleen, placenta and ovaries. Similarity: Belongs to the HMGN family. Gene ID: 9324 Database links: Entrez Gene: 515652 Cow Entrez Gene: 100723034 Guinea pig Entrez Gene: 100069315 Horse Entrez 高迁移率族蛋白N3抗体Gene: 9324 Human Entrez Gene: 94353 Mouse Entrez Gene: 100512571 Pig Entrez Gene: 113990 Rat Entrez Gene: 492345 Zebrafish Omim: 604502 Human SwissProt: Q3ZBV4 Cow SwissProt: Q15651 Human SwissProt: Q9DCB1 Mouse SwissProt: Q66H40 Rat Unigene: 77558 Human Unigene: 244426 Mouse Unigene: 106652 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
高迁移率族蛋白N3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 生长因子和** 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid