高迁移率族蛋白2抗体
规格：1mg/1ml
英文名： HMGB2
别名： High mobility group (nonhistone chromosomal) protein 2; High mobility group box 2; High mobility group protein 2; High mobility group protein B2; HMG 2; HMG B2; HMG-2; HMG2; HMGB2; HMGB2_HUMAN.
分子量： 24kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HMGB2
交叉反应：Human, Mouse, Rat, Cow, Rabbit, Sheep, hu, mo, rat, cow, hrs, shp, Rb
细胞定位：细胞核
高迁移率族蛋白2抗体产品介绍：background: This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008] Function: DNA binding 高迁移率族蛋白2抗体proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Subcellular Location: Nucleus. Chromosome. Similarity: Belongs to the HMGB family.高迁移率族蛋白2抗体 Contains 2 HMG box DNA-binding domains. Gene ID: 3148 Database links: Entrez Gene: 3148 Human Entrez Gene: 540444 Cow Entrez Gene: 97165 Mouse Omim: 163906 Human SwissProt: P40673 Cow SwissProt: P26583 Human SwissProt: P30681 Mouse Unigene: 434953 Human Unigene: 279998 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
高迁移率族蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid