血清类粘蛋白1样蛋白3抗体
规格：1mg/1ml
英文名： ORMDL3
别名： ORM1 (S. cerevisiae)-like 3; ORM1-like 3 (S. cerevisiae); ORM1-like protein 3; Ormdl3; ORML3_HUMAN; OTTHUMP00000164334.
分子量： 17kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ORMDL3
交叉反应：Human, Mouse, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep,
细胞定位：细胞膜
血清类粘蛋白1样蛋白3抗体产品介绍：background: The ORMDL (ORM1-like) family of proteins consist of ORMDL1, ORMDL2 and ORMDL3; all of which are human homologs of the S. cerevisiae ORM1 protein. Localized to the membrane of the endoplasmic reticulum, ORMDLs are multi-pass membrane proteins that are implicated in ?secretase (BACE) function, as well as expression of Presenilin (PSI), a protein involved in Alzheimer抯 disease (AD). ORMDL1 (ORM1-like protein 1), also known as Adoplin-1, is a widely expressed 153 amino acid member of the ORMDL family. Expression of ORMDL1 is down-regulated in PSI mutations, suggesting a possible role as a therapeutic target for AD. ORMDL2 (ORM1-like protein 2), also known as Adoplin-2, and ORMDL3 (ORM1-like protein 3) are expressed in tissues such as heart, brain, lung, liver and kidney. ORMDL3 exists as two isoforms due to alternative splicing events and may be a determinant of susceptibility to childhood asthma. Function: Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling. Subcellular Location: Endoplasmic 血清类粘蛋白1样蛋白3抗体reticulum membrane. Tissue Specificity: Widely expressed. Expressed in ***** and fetal heart, brain, lung, liver, skeletal muscle and kidney. Expressed in ***** pancreas and placenta and in fetal spleen abd thymus. DISEASE: Genetic variations in ORMDL3 are associated with susceptibility to asthma (ASTHMA) [MIM:600807]. The most common chronic disease affecting children and young *****s. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is血清类粘蛋白1样蛋白3抗体 characterized by recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi. Similarity: Belongs to the ORM family. Gene ID: 94103 Database links: Entrez Gene: 94103 Human Entrez Gene: 66612 Mouse Omim: 610075 Human SwissProt: Q8N138 Human SwissProt: Q9CPZ6 Mouse Unigene: 514151 Human Unigene: 180546 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
血清类粘蛋白1样蛋白3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导
储存条件： Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid