血清类粘蛋白1样蛋白2抗体
规格：1mg/1ml
英文名： ORMDL2
别名： Adoplin-2; HSPC160; MST095; MSTP095; ORM1-like protein 2; Ormdl2; ORML2_HUMAN.
分子量： 17kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ORMDL2
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆
血清类粘蛋白1样蛋白2抗体产品介绍：background: The ORMDL (ORM1-like) family of proteins consist of ORMDL1, ORMDL2 and ORMDL3; all of which are human homologs of the S. cerevisiae ORM1 protein. Localized to the membrane of the endoplasmic reticulum, ORMDLs are multi-pass membrane proteins that are implicated in ?secretase (BACE) function, as well as expression of Presenilin (PSI), a protein involved in Alzheimer抯 disease (AD). ORMDL1 (ORM1-like protein 1), also known as Adoplin-1, is a widely expressed 153 amino acid member of the ORMDL family. Expression of ORMDL1 is down-regulated in PSI mutations, suggesting a possible role as a therapeutic target for AD. ORMDL2 (ORM1-like protein 2), also known as Adoplin-2, and ORMDL3 (ORM1-like protein 3) are expressed in tissues such as heart, brain, lung, liver and kidney.血清类粘蛋白1样蛋白2抗体 ORMDL3 exists as two isoforms due to alternative splicing events and may be a determinant of susceptibility to childhood asthma. Function: Negative regulator of sphingolipid synthesis. Subcellular Location: Endoplasmic reticulum membrane. Tissue Specificity: Widely expressed. Expressed in ***** and fetal heart, brain, lung, liver, skeletal muscle and kidney. Expressed in ***** pancreas and placenta and in 血清类粘蛋白1样蛋白2抗体fetal spleen abd thymus. Similarity: Belongs to the ORM family. Gene ID: 29095 Database links: Entrez Gene: 29095 Human Entrez Gene: 66844 Mouse Omim: 610074 Human SwissProt: Q53FV1 Human SwissProt: Q9CQZ0 Mouse Unigene: 534450 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
血清类粘蛋白1样蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 新陈代谢
储存条件： Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid