粘蛋白20抗体
规格：1mg/1ml
英文名： MUC20
别名： MUC 20; MUC-20; Muc20; MUC20_HUMAN; Mucin 20; Mucin 20, cell surface associated; Mucin-20; Transmembrane mucin MUC20S.
分子量： 69kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MUC20
交叉反应：Human,
细胞定位：分泌型蛋白
粘蛋白20抗体产品介绍：background: This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The C-terminus of this family member associates with the multifunctional docking site of the MET proto-oncogene and suppresses activation of some downstream MET signaling cascades. The protein features a mucin tandem repeat domain that varies between two and six copies in most individuals. Multiple variants encoding different isoforms have been found for this gene. A related pseudogene, which is also located on chromosome 3, has been identified. [provided by RefSeq,粘蛋白20抗体 Apr 2014] Function: May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression. Subunit: Interacts with MET; oligomerization increases affinity for MET. Subcellular Location: Secreted. Apical cell membrane. Basolateral cell membrane. Cell projection > microvillus membrane. Tissue Specificity: Highly expressed in kidney, moderately in placenta, lung, prostate, liver, and 粘蛋白20抗体digestive system. In the kidney, localized in the proximal tubules but not in the glomerulus or distal tubules. Detected in most of the male urogenital tract epithelia, with the exception of epididymis. Gene ID: 200958 Database links: Entrez Gene: 200958 Human Entrez Gene: 224116 Mouse Omim: 610360 Human SwissProt: Q8N307 Human SwissProt: Q8BUE7 Mouse Unigene: 308992 Human Unigene: 153301 Mouse Unigene: 484124 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
粘蛋白20抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid