亚甲基四氢叶酸脱氢酶抗体
规格：1mg/1ml
英文名： MTHFD1
别名： 5,10 methylenetetrahydrofolate dehydrogenase 5,10 methylenetetrahydrofolate cyclohydrolase,10 formyltetrahydrofolate synthetase; C 1 tetrahydrofolate synthase cytoplasmic; C1 tetrahydrofolate synthase
分子量： 110kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MTHFD1
交叉反应：Human, Mouse, Rat, Cow, Xenopus laevis, Orangutan
细胞定位：细胞浆
亚甲基四氢叶酸脱氢酶抗体产品介绍：background: This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain. [provided by RefSeq, Jul 2008] Subcellular Location: Cytoplasm. Tissue Specificity: Ubiquitous. DISEASE: Defects in MTHFD1 may be a cause of susceptibility to folate-sensitive neural tube defects (folate-sensitive NTD) [MIM:601634]. The most common NTDs are open spina bifida (myelomeningocele) 亚甲基四氢叶酸脱氢酶抗体and anencephaly. Genetic defects in MTHFD1 may affect the risk of spina bifida via the maternal rather than the embryonic genotype. Genetic variation in MTHFD1 could be associated with susceptibility to colorectal cancer (CRC) [MIM:114500]. Similarity: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family. Gene ID: 4522 Database links: Entrez Gene: 534382 Cow Entrez Gene: 4522 Human Entrez Gene: 108156 Mouse Entrez Gene:亚甲基四氢叶酸脱氢酶抗体 100173036 Orangutan Entrez Gene: 64300 Rat Entrez Gene: 380266 Xenopus laevis Omim: 172460 Human SwissProt: P11586 Human SwissProt: Q922D8 Mouse SwissProt: P27653 Rat Unigene: 652308 Human Unigene: 29584 Mouse Unigene: 1114 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
亚甲基四氢叶酸脱氢酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 新陈代谢
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid