MSH4蛋白抗体
规格：1mg/1ml
英文名： MSH4
别名： MSH 4; MutS homolog 4 (E. Coli); MutS homolog 4; MutS protein homolog 4.
分子量： 105kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MSH4
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Sheep,
细胞定位：细胞核
MSH4蛋白抗体产品介绍：background: This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair. [provided by RefSeq, Aug 2011] Function: The Escherichia coli MutHLS system has been highly conserved throughout evolution. The eukaryotic pathway results in a specialization of MutS homologs such as MSH2 that have evolved to play crucial roles in both DNA mismatchMSH4蛋白抗体 repair and meiotic recombination. In Saccharomyces cerevisiae, MSH4 is a meiosis-specific protein that is not involved in mismatch correction. This protein is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. Subunit: Heterooligomer of MSH4 and MSH5. Subcellular Location: Nuclear Tissue Specificity: Testis and ovary specific. Similarity: Belongs to the MSH4蛋白抗体DNA mismatch repair MutS family. Gene ID: 4438 Database links: Entrez Gene: 4438 Human Entrez Gene: 55993 Mouse Omim: 602105 Human SwissProt: O15457 Human SwissProt: Q99MT2 Mouse Unigene: 216639 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
MSH4蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid