活化B**细胞因子1抗体
规格：1mg/1ml
英文名： MSC/Musculin
别名： ABF-1; ABF1; Activated B cell factor 1; Activated B-cell factor 1; bHLHa22; Class A basic helix-loop-helix protein 22; Msc; MUSC_HUMAN; Musculin; MYOR.
分子量： 21kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from mouse MSC/Musc
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Guinea Pig,
细胞定位：细胞核
活化B**细胞因子1抗体产品介绍：background: Differentiation of myogenic cells is regulated by multiple positively and negatively acting factors. One well characterized family of helix-loop-helix (HLH) proteins, known to play an important role in the regulation of muscle cell development, includes Myo D, myogenin and musculin (also designated MyoR). Members of this group of transcription factors form heterodimers with products of a more widely expressed family of bHLH genes, the E family, which consists of at least three distinct genes: E2A, IF2 and HEB. Myo D-E or musculin-E heterodimers bind avidly to consensus E box motifs, which are functionally important elements in the promoter regions of many muscle-specific terminal differentiation genes. Myo D complexes potently induce transcriptional activation, while musculin complexes bind adjacent to Myo D DNA-binding regions to represses Myo D activity, which then results in the delayed expression of muscle-specific genes. Musculin is highly 活化B**细胞因子1抗体expressed in undifferentiated and proliferating myoblasts in culture, and its expression is down regulated during myogenesis and at the onset of terminal differentiation. Function: Transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. May play a role in regulating antigen-dependent B-cell differentiation. Subcellular Location: Nucleus. Tissue Specificity: Expressed in lymphoid tissues活化B**细胞因子1抗体, B-cell lines and activated B-cells. Similarity: Contains 1 basic helix-loop-helix (bHLH) domain. Gene ID: 17681 Database links: Entrez Gene: 17681 Mouse SwissProt: O88940 Mouse Unigene: 5820 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
活化B**细胞因子1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 **细胞 b-**细胞 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid