莫洛尼白血病病毒蛋白10抗体
规格：1mg/1ml
英文名： Mov10
别名： DKFZp667O1423; FLJ32791; fSAP113; Functional spliceosome-associated protein 113; gb110; MGC2948; MOV10_MOUSE; Moloney leukemia virus 10 protein; MOV 10; Mov10 (Moloney leukemia virus 10, mouse) homolo
分子量： 114kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from mouse Mov10
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞浆
莫洛尼白血病病毒蛋白10抗体产品介绍：background: MOV10 is a RNA helicase that is required for RNA-mediated gene silencing by RISC (RNA-induced silencing complex). Significantly, MOV10 is also required for the transcription and replication of the human hepatitis delta virus, also known as hepatitis D. Belonging to the same family as MOV10, MOV10L1 (Moloney leukemia virus 10-like protein 1) is a 1211 amino acid RNA helicase that is expressed as three isoforms. Interestingly, isoform 1 is expressed exclusively in testis and isoform 2 is specifically expressed in cardiac myocytes. Isoform 1 may play a role in male germ cell development, whereas isoform 2 has been shown to potentiate phenylephrine-induced hypertrophic response in cardiomyocytes. Each isoform contains a RNA interaction motif, ATP binding site and helicase motif through which it carries 莫洛尼白血病病毒蛋白10抗体out its function. Function: MOV10 may be an helicase with an important function in development and/or control of cell proliferation. RNA silencing processes are guided by small RNAs known as siRNAs and microRNAs (miRNAs). They reside in ribonucleoprotein complexes, which guide the cleavage of complementary mRNAs or affect stability and translation of partial complementary mRNAs. Argonaute (Ago) proteins are at the heart of silencing effector complexes and bind the single-stranded siRNA and miRNA. Ago1- and Ago2-containing complexes have been purified from human cells, resulting in the discovery of novel factors such as the putative RNA helicase MOV10, and the RNA recognition motif (RRM)-containing protein TNRC6B/KIAA1093. The new proteins localize, similar to Ago proteins, to mRNA-degrading cytoplasmic P bodies, and they are functionally required 莫洛尼白血病病毒蛋白10抗体to mediate miRNA-guided mRNA cleavage. Subcellular Location: Cytoplasmic Gene ID: 17454 Database links: Entrez Gene: 17454 Mouse Entrez Gene: 4343 Human Entrez Gene: 100458347 Orangutan Omim: 610742 Human SwissProt: Q0V8H6 Cow SwissProt: Q9HCE1 Human SwissProt: P23249 Mouse Unigene: 514941 Human Unigene: 1597 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
莫洛尼白血病病毒蛋白10抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **细胞 b-**细胞 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid