MORG1蛋白抗体
规格：1mg/1ml
英文名： MORG1
别名： MAPK organizer 1; MAPK organizer 1; MGC4238; Mitogen activated protein kinase organizer 1; Mitogen-activated protein kinase organizer 1; MORG 1; WD repeat domain-containing protein 83; wdr83; WDR83_HU
分子量： 34kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MORG1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核 细胞浆
MORG1蛋白抗体产品介绍：background: This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] Function: Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists.MORG1蛋白抗体 At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing. Subunit: Interacts with EGLN3/PHD3. Interacts with ERK signaling proteins MAP2K1/MEK1, MAP2K2/MEK2, LAMTOR3, ARAF/Raf-1, MAPK1/ERK2 and MAPK3/ERK1 (By similarity). Identified in the spliceosome C complex. Subcellular Location: Cytoplasm. Nucleus. Predominantly cytoplasmic (By similarity). Partially nuclear. MORG1蛋白抗体Similarity: Belongs to the WD repeat MORG1 family. Contains 7 WD repeats. Gene ID: 84292 Database links: Entrez Gene: 84292 Human Entrez Gene: 67836 Mouse Entrez Gene: 288924 Rat SwissProt: Q9BRX9 Human SwissProt: Q9DAJ4 Mouse SwissProt: Q5BLX8 Rat Unigene: 657204 Human Unigene: 334680 Mouse Unigene: 3570 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
MORG1蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 激酶和磷酸酶 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid