纤维母细胞表面蛋白/Fibroblast Surface Protein抗体
规格：1mg/1ml
英文名： Spastin
别名： Spastin; FSP; Fibroblast surface protein; ADPSP; FSP 2; FSP2; KIAA1083; Spast; Spastic paraplegia 4; SPG 4; SPG4; SPAST_HUMAN.
分子量： 68kD
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FSP
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞核 细胞浆 细胞膜
纤维母细胞表面蛋白/Fibroblast Surface Protein抗体产品介绍：background: This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. The encoded ATPase may be involved in the assembly or function of nuclear protein complexes. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequences have not been determined. Mutations associated with this gene cause the most frequent form of autosomal dominant spastic paraplegia 4. [provided by RefSeq, Jul 2008] Subunit: Homohexamer. Binding to ATP stabilizes the homohexameric form. Binds to microtubules at least in part via the alpha-tubulin and beta-tubulin tails. The hexamer may adopt a ring conformation through which microtubules pass prior to being severed. Does not interact strongly with tubulin heterodimers. Interacts纤维母细胞表面蛋白/Fibroblast Surface Protein抗体 (via MIT domain) with CHMP1B; the interaction is direct. Interacts with ATL1, RTN1, SSNA1 and ZFYVE27. Subcellular Location: Membrane; Single-pass membrane protein (Potential). Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Endoplasmic reticulum. Endosome. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Localization to the centrosome is independent of microtubules. Localizes to the midbody of dividing cells, and this requires CHMP1B. Enriched in the distal axons and branches 纤维母细胞表面蛋白/Fibroblast Surface Protein抗体of postmitotic neurons. Isoform 3 is the main endosomal form. Tissue Specificity: Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. The short isoforms may predominate in brain and spinal cord. Similarity: Belongs to the AAA ATPase family. Spastin subfamily. Contains 1 MIT domain. Gene ID: 6683 Database links: Entrez Gene: 6683 Human Entrez Gene: 50850 Mouse Entrez Gene: 362700 Rat Omim: 604277 Human SwissProt: Q9UBP0 Human SwissProt: Q9QYY8 Mouse SwissProt: B2RYN7 Rat Unigene: 468091 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
纤维母细胞表面蛋白/Fibroblast Surface Protein抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 生长因子和**
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid