髓样细胞核分化抗原抗体
规格：1mg/1ml
英文名： MNDA
别名： MNDA; MNDA_HUMAN; Myeloid cell nuclear differentiation antigen; OTTHUMP00000024384; PYHIN3.
分子量： 46kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MNDA
交叉反应：Human,
细胞定位：细胞核 细胞浆
髓样细胞核分化抗原抗体产品介绍：background: The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. [provided by 髓样细胞核分化抗原抗体RefSeq, Jul 2008] Function: May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1. Subcellular Location: Nucleus. Cytoplasm. Uniformly distributed throughout the interphase cell nucleus. Associates with chromatin. Tissue Specificity: Expressed 髓样细胞核分化抗原抗体constitutively in cells of the myeloid lineage. Found in promyelocyte stage cells as well as in all other stage cells including peripheral blood monocytes and granulocytes. Also appear in myeloblast cells in some cases of acute myeloid Leukemia. Similarity: Contains 1 DAPIN domain. Contains 1 HIN-200 domain. Gene ID: 4332 Database links: Entrez Gene: 4332 Human Omim: 159553 Human SwissProt: P41218 Human Unigene: 153837 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
髓样细胞核分化抗原抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 干细胞 结合蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid