剪接因子1抗体
规格：1mg/1ml
英文名： splicing factor 1
别名： BBP; D11S636; Mammalian branch point-binding protein mBBP; OTTHUMP00000069749; OTTHUMP00000069750; OTTHUMP00000069752; splicing factor 1; SF01_HUMAN; Transcription factor ZFM1; ZFM1; Zinc finger gene
分子量： 68kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human splicing
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, Danio
细胞定位：细胞核
剪接因子1抗体产品介绍：background: This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence and is required for the early stages of spliceosome assembly. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010] Function: SF1 contains 1 KH domain, 1 CCHC type zinc finger, a nuclear transport domain and glutamine and proline rich regions. It is necessary for the ATP dependent first step of spliceosome assembly and binds to the intron branch point sequence (BPS) 5' UACUAAC 3' of the pre mRNA. It may act as transcription repressor. There are 6 named isoforms produced by alternative splicing. Subcellular Location: Nuclear Tissue Specificity: Detected in lung, ovary, adrenal gland, colon, kidney, muscle, pancreas, thyroid, placenta, brain,剪接因子1抗体 liver and heart. Post-translational modifications: Phosphorylation on Ser-20 interferes with U2AF2 binding and spliceosome assembly. Isoform 6 is phosphorylated on Ser-463. Similarity: Belongs to the BBP/SF1 family. Contains 1 CCHC-type zinc finger. Contains剪接因子1抗体 1 KH domain. Gene ID: 7536 Database links: Entrez Gene: 7536 Human Entrez Gene: 22668 Mouse Omim: 601516 Human SwissProt: Q15637 Human SwissProt: Q64213 Mouse Unigene: 502829 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
剪接因子1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 转录调节因子 锌指蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid