转录因子SPIB蛋白抗体
规格：1mg/1ml
英文名： SPIB
别名： SPI B; Spi B transcription factor; Spib; SPIB_HUMAN; Transcription factor Spi-B.
分子量： 29kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SPIB
交叉反应：Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核 细胞浆
转录因子SPIB蛋白抗体产品介绍：background: The protein encoded by this gene is a transcriptional activator that binds to the PU-box (5'-GAGGAA-3') and acts as a lymphoid-specific enhancer. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] Function: Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation.转录因子SPIB蛋白抗体 Subcellular Location: Cytoplasm and Nucleus. Tissue Specificity: Expressed in plasmacytoid dendritic cells (pDCs) and B-cells, not expressed in T-cells or granulocytes. May also be enriched in stem cell populations of the liver. Similarity: Belongs to the ETS 转录因子SPIB蛋白抗体family. Contains 1 ETS DNA-binding domain. Gene ID: 6689 Database links: Entrez Gene: 6689 Human Entrez Gene: 272382 Mouse Entrez Gene: 499146 Rat Omim: 606802 Human SwissProt: Q01892 Human SwissProt: O35906 Mouse SwissProt: Q5EBA3 Rat Unigene: 437905 Human Unigene: 8012 Mouse Unigene: 18257 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
转录因子SPIB蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid