大肠癌相关蛋白抗体
规格：1mg/1ml
英文名： SPG11
别名： Colorectal carcinoma associated protein; Colorectal carcinoma-associated protein; DKFZp762B1512; FLJ21439; KIAA1840; Spastic paraplegia 11 (autosomal recessive); Spastic paraplegia 11; Spastic paraple
分子量： 279kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SPG11
交叉反应：Human, Mouse, Dog, Pig, Cow,
细胞定位：细胞浆 细胞膜
大肠癌相关蛋白抗体产品介绍：background: The protein encoded by this gene is a potential transmembrane protein that is phosphorylated upon DNA damage. Defects in this gene are a cause of spastic paraplegia type 11 (SPG11). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] Subunit: Interacts with AP5Z1, AP5B1, AP5S1 and ZFYVE26. Subcellular Location: Membrane. Cytoplasm > cytosol. Nucleus. Mainly cytoplasmic. Tissue Specificity: Expressed in all structures of brain, with a high expression in cerebellum. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. DISEASE: Defects in大肠癌相关蛋白抗体 SPG11 are the cause of spastic paraplegia autosomal recessive type 11 (SPG11) [MIM:604360]. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the 大肠癌相关蛋白抗体severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Gene ID: 80208 Database links: Entrez Gene: 80208 Human Omim: 610844 Human SwissProt: Q96JI7 Human Unigene: 656271 Human Unigene: 683876 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
大肠癌相关蛋白抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid