精子赤道区域蛋白1抗体
规格：1mg/1ml
英文名： SPESP1
别名： Equatorial segment protein; ESP; Glycosylated 38 kDa sperm protein C 7/8; Glycosylated 38 kDa sperm protein C-7/8; MGC24663; SP-ESP; Sperm equatorial segment protein 1; Sperm equatorial segment protei
分子量： 37kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SPESP1
交叉反应：Human, Rat, Rabbit,
细胞定位：
精子赤道区域蛋白1抗体产品介绍：background: SPESP1 is a 399 amino acid protein belonging to the SPESP1 family. Localizing to cytoplasmic vesicle, secretory vesicle, and acrosome, SPESP1 is highly expressed in testis, with lower levels found in placenta and fetal lung. SPESP1 establishes an equatorial segment subcompartment early in sperm development and is required for proper sperm-egg fusion. Disruption of SPESP1 leads to abnormal distribution of sperm proteins resulting in a detached membrane from the equatorial segment and less fertile sperm. SPESP1 may interact with IZUMO1 and MN9 antigen and contains an N-glycosylation site as well as several cAMP-dependent kinase, protein kinase C, and casein kinase II consensus phosphorylation sites. Function: The encoded protein is a human alloantigen involved in sperm-egg binding and fusion.精子赤道区域蛋白1抗体 [provided by RefSeq, Apr 2010] Subcellular Location: Cytoplasmic vesicle > secretory vesicle > acrosome. Small proacrosomal granules (during the Golgi phase), enlarged acrosomal vesicles (during the cap phase), acrosome (during the elongating phase), 精子赤道区域蛋白1抗体equatorial segment of the acrosome. Tissue Specificity: Highly expressed in testis, where it is localized in the acrosome of postmeiotic stages of spermiogenesis (round and elongating spermatids and in ejaculated spermatozoa) (at protein level). Poorly expressed in placenta and fetal lung. Similarity: Belongs to the SPESP1 family. Gene ID: 246777 Database links: Entrez Gene: 246777 Human Omim: 609399 Human SwissProt: Q6UW49 Human Unigene: 657932 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
精子赤道区域蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 结合蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid