精子顶体膜相关蛋白3抗体
规格：1mg/1ml
英文名： SPACA3
别名： 1700025M08Rik; ALLP17; Cancer/testis antigen 54; sperm acrosome associated 3; CT54; LYC3; Lysozyme like sperm specific secretory protein ALLP17; Lysozyme-like acrosomal sperm-specific secretory protei
分子量： 23kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SPACA3
交叉反应：Human,
细胞定位：细胞膜 细胞外基质
精子顶体膜相关蛋白3抗体产品介绍：background: SPACA3 is a 215 amino acid protein that participates in the fusion and adhesion of sperm and egg plasma membrane during fertilization. Identified as a novel cancer/testis antigen in hematologic malignancies, SPACA3 has the ability to elicit B-cell immune responses in patients with cancer and is considered a potential target for immunotherapy. A member of the glycosyl hydrolase 22 family which is expressed in testis, placenta and epididymis, SPACA3 exists as two alternatively spliced isoforms; SPACA3 isoform 1 is a single-pass type II membrane protein of the sperm acrosome whereas SPACA3 isoform 2 is a secreted protein. Function:精子顶体膜相关蛋白3抗体 Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro. Subcellular Location: Secreted and Cytoplasmic vesicle > secretory vesicle > acrosome membrane. Anterior acrosome in non-capacitated spermatozoa and retained in the equatorial segment and in the luminal face of both the inner and outer acrosomal membranes following capacitation and the acrosome reaction. Tissue Specificity: The processed form is expressed in sperm (at protein level). Expressed in testis, epididymis and placenta. Post-translational modifications: The processed form derives from the精子顶体膜相关蛋白3抗体 membrane form by proteolytic processing. Similarity: Belongs to the glycosyl hydrolase 22 family. Gene ID: 124912 Database links: Entrez Gene: 124912 Human Omim: 612749 Human SwissProt: Q8IXA5 Human Unigene: 434112 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
精子顶体膜相关蛋白3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 发育生物学 信号转导 新陈代谢
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid