磷酸化视网膜母细胞瘤相关蛋白p130抗体
规格：1mg/1ml
英文名： phospho-Rb2 p130 (Ser952)
别名： Rb2 p130 (phospho S952); p-Rb2 p130 (phospho S952); p130; PRB2; Rb2; RBL2; RBR2; Retinoblastoma like 2; Retinoblastoma like protein 2.
分子量： 128kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KKLH conjugated synthesised phosphopeptide derived from huma
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核
磷酸化视网膜母细胞瘤相关蛋白p130抗体产品介绍：background: p130 is related both in structure and function to the retinoblastoma tumor suppressor protein and p107 (collectively known as pocket proteins) and is known to regulate the activity of E2F transcription factors. E2F transcription factors regulate the expression of a number of genes important in cell proliferation, particularly those involved in the progression through G1 and into the S phase of the cell cycle. Binding of p130 converts E2F transcription factors from transcriptional activators to transcriptional repressors. Function: Two retinoblastoma related proteins, p107 and pRb2 / p130, which are structurally and functionally similar to the product of the retinoblastoma gene (pRb / p105), were cloned by taking advantage of their ability to bind transforming proteins of DNA tumor磷酸化视网膜母细胞瘤相关蛋白p130抗体 viruses through a particular region called the "pocket domain." Like pRb, both proteins play a fundamental role in growth control. These Rb family proteins were measured in a variety of lung neoplasms. The highest percentage of undetectable levels and the tightest inverse correlation with the histological grading and with PCNA expression in the most aggressive tumor types were found for pRb2 / p130磷酸化视网膜母细胞瘤相关蛋白p130抗体, which may suggest an important role for this protein in the pathogenesis and progression of lung cancer. Subcellular Location: Nuclear Gene ID: 5934 Database links: Entrez Gene: 5934 Human Entrez Gene: 5934 Human Entrez Gene: 19651 Mouse Omim: 180203 Human SwissProt: Q08999 Human SwissProt: 235580 Mouse SwissProt: Q64700 Mouse Unigene: 283604 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸化视网膜母细胞瘤相关蛋白p130抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid