内皮素受体A抗体
规格：1mg/1ml
英文名： EDNRA
别名： Endothelin receptor type A; EDNRA; Endothelin 1 receptor precursor; EDNR-A; Endothelin A receptor; Endothelin receptor type A; ET A; ETA; ET-A; ETA-R; ETA R; ETRA; hET AR; Ednra; EDNRA_HUMAN; Endothel
分子量： 47kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human EDNRA
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞膜
产品介绍：background: This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This 内皮素受体A抗体receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] Function: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. Subunit: Interacts with HDAC7 and KAT5. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Isoform 1, isoform 3 内皮素受体A抗体and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but no expression in umbilical vein endothelial cells. Within the placenta, isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in the villi and stem villi vessels. Similarity: Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily. Gene ID: 1909 Database links: Entrez Gene: 281749 Cow内皮素受体A抗体 Entrez Gene: 450187 Dog Entrez Gene: 1909 Human Entrez Gene: 13617 Mouse Entrez Gene: 397457 Pig Entrez Gene: 24326 Rat GenBank: NM_001957 Human GenBank: NM_174308 Human GenBank: NM_012550 Rat Omim: 131243 Human SwissProt: P21450 Cow SwissProt: Q5KSU9 Dog SwissProt: P25101 Human SwissProt: Q61614 Mouse SwissProt: Q29010 Pig SwissProt: P26684 Rat Unigene: 183713 Human Unigene: 283168 Mouse Unigene: 392296 Mouse Unigene: 10915 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
内皮素受体A抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 **学 生长因子和**
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid