去泛素酶A抗体
规格：1mg/1ml
英文名： OTUD5/DUBA
别名： Deubiquinating enzyme A; Deubiquitinating enzyme A; DKFZp761A052; DUBA; MGC104871; OTTHUMP00000025821; OTU domain containing 5; OTU domain containing protein 5; OTU domain-containing protein 5; OTUD 5
分子量： 61kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human OTUD5/DU
交叉反应：Human, Mouse, Rat, Chicken, Rabbit,
细胞定位：细胞核
去泛素酶A抗体产品介绍：background: This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008] Function: Negative regulator 去泛素酶A抗体of innate immune system. Has deubiquitinating activity that is directed towards 'Lys-63'-linked polyubiquitin chains. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Subunit: Interacts with TRAF3. Tissue Specificity: Expressed in various tissues, including the liver and placenta, as well as in peripheral blood leukocytes. Post-translational modifications: Phosphorylation at Ser-177 去泛素酶A抗体is required for deubiquitinating activity. Similarity: Belongs to the peptidase C85 family. Contains 1 OTU domain. Gene ID: 55593 Database links: Entrez Gene: 55593 Human Entrez Gene: 54644 Mouse Entrez Gene: 363452 Rat Omim: 300713 Human SwissProt: Q96G74 Human SwissProt: Q3U2S4 Mouse SwissProt: Q2YDU3 Rat Unigene: 496098 Human Unigene: 142827 Mouse Unigene: 97794 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
去泛素酶A抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 表观遗传学 泛素
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid