胶质细胞谷氨酸运载蛋白2抗体
规格：1mg/1ml
英文名： EAAT2
别名： EAAT2; Excitatory amino acid transporter 2; Excitotoxic amino acid transporter 2; Glial high affinity glutamate transporter; GLT 1; GLT1; Glutamate aspartate transporter II; SLC1A2; Sodium dependent g
分子量： 62kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human EAAT2
交叉反应：Human, Mouse, Rat, Cow, Horse, Rabbit,
细胞定位：细胞膜
胶质细胞谷氨酸运载蛋白2抗体产品介绍：background: This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Sep 2010] Function: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft胶质细胞谷氨酸运载蛋白2抗体. Acts as a symport by cotransporting sodium. Subunit: Homotrimer. Interacts with AJUBA. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Brain Post-translational modifications: Glycosylated. Palmitoylation at Cys-38 is not required for correct subcellular localization, but is important for glutamate uptake activity. Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A2 subfamily. Gene ID: 6506 Database links: Entrez Gene: 6506 Human Entrez Gene: 20511 Mouse Entrez Gene: 29482 Rat Omim: 600300 胶质细胞谷氨酸运载蛋白2抗体Human SwissProt: P43004 Human SwissProt: P43006 Mouse SwissProt: P31596 Rat Unigene: 502338 Human Unigene: 267547 Mouse Unigene: 371582 Mouse Unigene: 10240 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
胶质细胞谷氨酸运载蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 神经生物学 通道蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid