SKOR1蛋白抗体
规格：1mg/1ml
英文名： SKOR1
别名： AV273001; C230094B15Rik; Corepressor for LBX1; CORL1; Functional smad suppressing element 15; Functional Smad suppressing element on chromosome 15; Functional Smad-suppressing element on chromosome 15
分子量： 100kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from mouse SKOR1
交叉反应：Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig,
细胞定位：细胞核
SKOR1蛋白抗体产品介绍：background: LBXCOR1 is a 965 amino acid protein belonging to the SKI family. Localizing to nucleus, LBXCOR1 is highly expressed in the central nervous system (CNS) as well as developing spinal cord and ***** brain and testis. LBXCOR1 contains a CH1 domain which is required for transcriptional repression and also acts as a transcriptional co-repressor of LBX1. LBXCOR1 additionally interacts with SMAD1, SMAD2 and SMAD3, and inhibits BMP signaling. Existing as three alternatively spliced isoforms, the gene encoding LBXCOR1 maps to human chromosome 15q23. Encoding more than 700 genes, chromosome 15 is made up of approximately 106 million base pairs and SKOR1蛋白抗体consists of about 3% of the human genome. Angelman and Prader-Willi syndromes, as well as Tay-Sachs disease and Marfan syndorme, are all associated with mutations to chromosome 15. Function: Acts as a transcriptional corepressor of LBX1 (By similarity). Inhibits BMP signaling. Subcellular Location: Nucleus. Tissue Specificity: Present specifically in cerebellar Purkinje cells (at protein level). Similarity: Belongs to SKOR1蛋白抗体the SKI family. Database links: Entrez Gene: 207667 Mouse Entrez Gene: 315748 Rat SwissProt: Q8BX46 Mouse SwissProt: P84551 Rat Unigene: 36349 Mouse Unigene: 447200 Mouse Unigene: 58197 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
SKOR1蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：发育生物学 神经生物学 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid