信号调节蛋白β2/SIRP-β2抗体
规格：1mg/1ml
英文名： SIRPB2
别名： BIG 3; dJ776F14.2; Protein tyrosine phosphatase non-receptor type substrate 1-like 3; Protein tyrosine phosphatase non-receptor type substrate protein; PTPNS1L3; RP4-776F14.1; Signal-regulatory protei
分子量： 37kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SIRPB2
交叉反应：Human,
细胞定位：细胞膜
信号调节蛋白β2/SIRP-β2抗体产品介绍：background: SIRPs are a family of transmembrane glycoproteins that were identified by their association with the Src homology 2 domain-containing protein-tyrosine phosphatase SHP-2 in response to insulin. The SIRP family negatively regulates the PI 3-kinase pathway, which may diminish EGFR-mediated motility and survival phenotypes that contribute to transformation of certain cell types. SIRP-alpha 1 is a transmembrane protein which acts as a substrate for activated receptor tyrosine kinases and, in its tyrosine信号调节蛋白β2/SIRP-β2抗体 phosphorylated form, binds to SH-PTP2 through SH2 interactions and acts as an SH-PTP2 substrate. SIRP-alpha 1 has been shown to have negative regulatory effects on cellular responses induced by growth factors, oncogenes and Insulin. SIRP-beta 1 shares extensive sequence homology with SIRP-alpha 1 in its extracellular portion but lacks the cytoplasmic portion. SIRP-beta 2 is a 342 amino 信号调节蛋白β2/SIRP-β2抗体acid multi-pass membrane protein that contains two Ig-like V-type (immunoglobulin-like) domains and exists as multiple alternatively spliced isoforms. Subcellular Location: Membrane. Similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains. Database links: Entrez Gene: 284759 Human SwissProt: Q5JXA9 Human Unigene: 721685 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
信号调节蛋白β2/SIRP-β2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid