丝裂原活化蛋白激酶相关蛋白1抗体
规格：1mg/1ml
英文名： MAPKAP1/SIN1
别名： MAPKAP 1; MAPKAP1; MEKK2 interacting protein 1; MGC2745; MIP 1; MIP1; Mitogen activated protein kinase associated protein 1; Mitogen-activated protein kinase 2-associated protein 1; mSIN1; OTTHUMP0000
分子量： 30/50/65kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MAPKAP1/
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, Cat, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Platypus
细胞定位：细胞核 细胞浆 细胞膜
丝裂原活化蛋白激酶相关蛋白1抗体产品介绍：background: This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene. [provided by RefSeq, Jul 2008] Function: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 丝裂原活化蛋白激酶相关蛋白1抗体'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Subcellular Location: Cell membrane. Cytoplasmic vesicle. Nucleus. 丝裂原活化蛋白激酶相关蛋白1抗体Tissue Specificity: Ubiquitously expressed, with highest levels in heart and skeletal muscle. Similarity: Belongs to the SIN1 family. Gene ID: 79109 Database links: Entrez Gene: 395627 Chicken Entrez Gene: 79109 Human Entrez Gene: 227743 Mouse Entrez Gene: 296648 Rat Omim: 610558 Human SwissProt: Q9W6S3 Chicken SwissProt: Q9BPZ7 Human SwissProt: Q8BKH7 Mouse SwissProt: Q6AYF1 Rat Unigene: 495138 Human Unigene: 270866 Mouse Unigene: 105886 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
丝裂原活化蛋白激酶相关蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit