组蛋白H2家族A.V抗体
规格：1mg/1ml
英文名： Histone H2A.V
别名： H2A.F/Z; h2afv; H2AV; H2AV_HUMAN; Histone H2A.V.
分子量： 14kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Histone
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Zebrafish, Xenopus laevis
细胞定位：细胞核
组蛋白H2家族A.V抗体产品介绍：Function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer组蛋白H2家族A.V抗体 wraps approximately 147 bp of DNA. H2A or its variant H2AFV forms a heterodimer with H2B (By similarity). Subcellular Location: Nucleus. Chromosome. Post-translational modifications: Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression. Similarity: Belongs to the histone H2A family. Gene ID: 94239 Database links: Entrez Gene: 613618 Cow Entrez Gene: 94239 Human Entrez Gene: 组蛋白H2家族A.V抗体77605 Mouse Entrez Gene: 100328558 Rabbit Entrez Gene: 444541 Xenopus laevis Entrez Gene: 548932 Xenopus tropicalis Entrez Gene: 252913 Zebrafish SwissProt: Q32LA7 Cow SwissProt: Q71UI9 Human SwissProt: Q3THW5 Mouse SwissProt: O62695 Rabbit SwissProt: Q6GM74 Xenopus laevis SwissProt: Q5BJ65 Xenopus tropicalis SwissProt: Q71PD7 Zebrafish Unigene: 488189 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
组蛋白H2家族A.V抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 表观遗传学 泛素
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid