组蛋白H1抗体
规格：1mg/1ml
英文名： Histone H1
别名： dJ221C16.2; dJ221C16.5; DmeH1; H1 0 histone; H1; H1 histone family member 0; H1 histone family member 1; H1 histone family member 3; H1 histone family member 5; H1 histone family member N testis speci
分子量： 36kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Histone
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核 细胞浆
组蛋白H1抗体产品介绍：background: Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008] Function: May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may 组蛋白H1抗体contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling. Subcellular Location: Cytoplasm. Nucleus. Chromosome. Tissue Specificity: Oocyte-specific. Similarity: Belongs to the histone H1/H5 family. Contains 1 H15 (linker histone H1/H5 globular) domain. Gene ID: 132243 Database links: Entrez Gene: 132243 Human Entrez Gene: 3005 Human Entrez Gene: 3006 Human Entrez Gene: 3007 Human Entrez Gene: 3008 Human Entrez Gene: 3009 Human Entrez Gene: 3010 Human Entrez Gene: 3024 Human Entrez Gene: 341567 Human Entrez Gene: 8971 Human Omim: 142210 Human Omim: 142220 Human 组蛋白H1抗体Omim: 142708 Human Omim: 142709 Human Omim: 142710 Human Omim: 142711 Human Omim: 602785 Human SwissProt: P07305 Human SwissProt: P10412 Human SwissProt: P16401 Human SwissProt: P16402 Human SwissProt: P16403 Human SwissProt: P22492 Human SwissProt: Q02539 Human SwissProt: Q147U8 Human SwissProt: Q2M2I2 Human SwissProt: Q3MJ34 Human SwissProt: Q3MJ42 Human SwissProt: Q4VB25 Human SwissProt: Q6FG88 Human SwissProt: Q6ISI1 Human SwissProt: Q7Z694 Human SwissProt: Q86WT7 Human SwissProt: Q8IZA3 Human SwissProt: Q8N6R3 Human SwissProt: Q92522 Human Unigene: 226117 Human Unigene: 97358 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
组蛋白H1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 表观遗传学 泛素
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid