磷酸化**基化组蛋白H3抗体
规格：1mg/1ml
英文名： Histone H3 (phospho T3, tri methyl K4)
别名： H3 histone family member E pseudogene; H3F3; HIST3H3; Histone H3 3 pseudogene; Histone H3; H3S; Histone H3-I/H3-II; Major histone H3; H3F; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histo
分子量： 17kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Histone
交叉反应：Human, Mouse, Rat, Chicken, Cow,
细胞定位：细胞核
磷酸化**基化组蛋白H3抗体产品介绍：background: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fibre is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. Covalent modifications of the canonical core histones, including acetylation, phosphorylation, methylation, and monoubiquitination, are used to mark nucleosomes to create chromatin domains with a range of functions. The information encoded by the modifications can contribute to the formation and/or maintenance of transcriptionally active and inactive chromatin in response to various signalling pathways. Phosphorylation, particularly that of histones H1 and H3, has long been 磷酸化**基化组蛋白H3抗体implicated in chromosome condensation during mitosis. However, converging evidence suggests that H3 phosphorylation (specifically serine 10) is also directly correlated with the induction of immediate-early genes such as c-jun, c-fos and c-myc. The potential importance of the serine 10 phosphorylation mark in H3 is strengthened by the finding that MSK1, a kinase activated by growth factor and stress stimuli, also phosphorylates H3 in vitro. H3 phosphorylation at serine 10 in conjunction with phosphorylation at serine 28, is also required for proper segregation and condensation of chromosomes during mitosis and meiosis. Database links: Entrez Gene: 176359 Caenorhabditis elegans Entrez Gene: 磷酸化**基化组蛋白H3抗体326601 Cow Entrez Gene: 45314 Fruit fly (Drosophila melanogaster) Entrez Gene: 10338 Human Entrez Gene: 3020 Human Entrez Gene: 3021 Human Entrez Gene: 15079 Mouse Entrez Gene: 15080 Mouse Omim: 601128 Human SwissProt: P08898 Caenorhabditis elegans SwissProt: Q10453 Caenorhabditis elegans SwissProt: P16105 Cow SwissProt: P16106 Cow SwissProt: P02299 Fruit fly (Drosophila melanogaster) SwissProt: P06351 Fruit fly (Drosophila melanogaster) SwissProt: P06351 Human SwissProt: P16106 Human SwissProt: Q16695 Human SwissProt: Q93081 Human SwissProt: P16105 Mouse SwissProt: P06351 Rat SwissProt: P16105 Xenopus laevis Unigene: 181307 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸化**基化组蛋白H3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid