组蛋白HIST1H2AL抗体
规格：1mg/1ml
英文名： HIST1H2AL
别名： H2A histone family, member P; H2A.1; H2A.1b; H2A/n; H2A/p; H2A1_HUMAN; H2AF; H2AFC; H2AFD ANDHIST1H2AL; H2AFD; H2AFI; H2AFN ANDHIST1H2AG; H2AFN; H2AFP; HIST1H2AI; HIST1H2AJ; HIST1H2AK; HIST1H2AL; HIST
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HIST1H2A
交叉反应：Human, Mouse, Rat,
细胞定位：细胞核
组蛋白HIST1H2AL抗体产品介绍：background: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008] Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template组蛋白HIST1H2AL抗体. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Subcellular Location: Nucleus. Chromosome. Post-translational modifications: The chromatin-associated form is phosphorylated on Thr-121 during mitosis. Deiminated on Arg-4 in granulocytes upon calcium entry. Monoubiquitination of Lys-120 by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of组蛋白HIST1H2AL抗体 'Lys-27' of histone H3. Monoubiquitination of Lys-120 by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Monoubiquitination and ionizing radiation-induced 'Lys-63'-linked ubiquitination are distinct events. Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage. Similarity: Belongs to the histone H2A family. Database links: Entrez Gene: 8329 Human Entrez Gene: 8330 Human Entrez Gene: 8332 Human Entrez Gene: 8336 Human Entrez Gene: 8969 Human Entrez Gene: 319164 Mouse Entrez Gene: 319165 Mouse Entrez Gene: 319166 Mouse Entrez Gene: 319167 Mouse Entrez Gene: 319170 Mouse Entrez Gene: 319171 Mouse Entrez Gene: 319172 Mouse Entrez Gene: 319173 Mouse Entrez Gene: 319191 Mouse Entrez Gene: 665433 Mouse Entrez Gene: 498753 Rat Omim: 602788 Human SwissProt: P0C0S8 Human SwissProt: P22752 Mouse SwissProt: Q8CGP5 Mouse SwissProt: P02262 Rat SwissProt: Q6I8Q6 Rat Unigene: 134999 Human Unigene: 233568 Human Unigene: 51011 Human Unigene: 534035 Human Unigene: 558421 Human Unigene: 14767 Mouse Unigene: 250564 Mouse Unigene: 261665 Mouse Unigene: 261973 Mouse Unigene: 263165 Mouse Unigene: 377877 Mouse Unigene: 390553 Mouse Unigene: 422826 Mouse Unigene: 423402 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
组蛋白HIST1H2AL抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid