17β羟基类固醇脱氢酶11/17β-HSD11抗体
规格：1mg/1ml
英文名： HSD17B11
别名： 17 beta HSD 11; 17 beta HSD XI; 17 BETA HSD11; 17 BETA HSDXI; 17 beta hydroxysteroid dehydrogenase 11; 17 beta hydroxysteroid dehydrogenase type XI; 17 beta hydroxysteroid dehydrogenase XI; 17-beta-HS
分子量： 31kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Hsd17b11
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：分泌型蛋白
产17β羟基类固醇脱氢酶11/17β-HSD11抗体品介绍：background: Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]).[supplied by OMIM, Jun 2009] Function: Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in 17β羟基类固醇脱氢酶11/17β-HSD11抗体cutaneous T-cell lymphoma. Subcellular Location: Secreted. Tissue Specificity: Present at high level in steroidogenic cells such as syncytiotrophoblasts, sebaceous gland, Leydig cells, and granulosa cells of the dominant follicle and corpus luteum. In lung, it is detected in the ciliated epithelium and in acini of ***** trachea, in bronchioles, but not in alveoli. In the eye, it is detected in the nonpigmented 17β羟基类固醇脱氢酶11/17β-HSD11抗体epithelium of the ciliary body and, at lower level, in the inner nuclear layer of the retina (at protein level). Widely expressed. Highly expressed in retina, pancreas, kidney, liver, lung, adrenal, small intestine, ovary and heart. Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. Gene ID: 51170 Database links: Entrez Gene: 51170 Human Entrez Gene: 114664 Mouse Entrez Gene: 289456 Rat Omim: 612831 Human SwissProt: Q8NBQ5 Human SwissProt: Q9EQ06 Mouse SwissProt: Q6AYS8 Rat Unigene: 594923 Human Unigene: 46019 Mouse Unigene: 102059 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
17β羟基类固醇脱氢酶11/17β-HSD11抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 生长因子和**
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid