热休克因子结合蛋白1抗体
规格：1mg/1ml
英文名： HSBP1
别名： Heat shock factor binding protein 1; Heat shock factor-binding protein 1; HSBP1; HSBP1_HUMAN; HSF1BP; Nasopharyngeal carcinoma associated antigen 13; Nasopharyngeal carcinoma-associated antigen 13; NP
分子量： 8.5kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HSBP1
交叉反应：Human,
细胞定位：细胞核
热休克因子结合蛋白1抗体产品介绍：background: Prokaryotic and eukaryotic cells respond to thermal and chemical stress by inducing a group of genes collectively designated heat shock genes. In eukaryotes, this gene expression is regulated primarily at the transcription level. Heat shock transcription factors 1 and 2 (HSF1 and HSF2), also designated HSTF1 and HSTF2, are involved in this regulation and are upregulated by estrogen at both the mRNA and protein level. HSF1 is normally found as a monomer, whose transcriptional activity is repressed by constitutive phosphorylation. Upon activation, HSF1 forms trimers, gains DNA binding activity and is translocated to the nucleus. HSBP1 (heat shock factor-binding protein 1), also known as HSF1BP or NPC-A-13 (nasopharyngeal carcinoma-associated antigen 13), is a 76 amino acid nuclear protein that binds热休克因子结合蛋白1抗体 HSF1 and acts as a negative regulator of the heat shock response. Function: Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process. Subunit: Homohexamer. Associates with heptad repeats of HSF1 trimers and problaby also HSF1 monomers, and with HSP70. Association with HSF1 trimers and HSP70 coincides with attenuation of heat shock response and the conversion of HSF1 trimer to monomer. Subcellular Location: Nucleus.热休克因子结合蛋白1抗体 Similarity: Belongs to the HSBP1 family. Gene ID: 3281 Database links: Entrez Gene: 3281 Human Entrez Gene: 100038001 Pig Entrez Gene: 286899 Rat Entrez Gene: 393727 Zebrafish Omim: 604553 Human SwissProt: Q3ZC22 Cow SwissProt: O75506 Human SwissProt: A1XQV7 Pig SwissProt: Q8K3X8 Rat Unigene: 250899 Human Unigene: 705549 Human Unigene: 2578 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
热休克因子结合蛋白1抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid