同源盒蛋白D12抗体
规格：1mg/1ml
英文名： HOXD12
别名： Homeobox protein Hox D12; Homeobox protein Hox-4H; Homeobox protein Hox-D12; Hox 4.7, mouse, homolog of; Hox 4H; HOX4H; HOXD12; HXD12_HUMAN.
分子量： 30kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HOXD12
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig,
细胞定位：细胞核
同源盒蛋白D12抗体产品介绍：background: The Hox (homeobox) genes play an important role in the development and design of anterior-posterior body axes in animals. Although Hox proteins can bind to DNA as monomers, dimerization with PBX homeoproteins can significantly increase the DNA binding activity of these transcription factors. The HoxD9 gene is involved in the development and patterning of the forelimb and axial skeleton. Transcriptional activation of HoxD9 has been shown to be enhanced by HMG1 (high mobility group protein 1) and antagonized by HoxD8, suggesting that Hox protein function depends on both DNA-protein and protein-protein interactions. The HOX genes are known to regulate a number of cell adhesion molecules (CAMs), with HoxD9 specifically increasing levels of L-CAM transcripts. In presomitic mesoderm, HoxD1 displays dynamic stripes of expression. In the three stages of diencephalon development, HoxD1 is strongly expressed in the first two同源盒蛋白D12抗体stages and downregulated in the third stage. Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Subcellular Location: Nucleus.同源盒蛋白D12抗体 Similarity: Belongs to the Abd-B homeobox family. Contains 1 homeobox DNA-binding domain. Database links: Entrez Gene: 3238 Human Entrez Gene: 15432 Mouse Entrez Gene: 366082 Rat Omim: 142988 Human SwissProt: P35452 Human SwissProt: P23812 Mouse Unigene: 450028 Human Unigene: 57124 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
同源盒蛋白D12抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 结合蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid