宿主细胞因子C1调节蛋白1抗体
规格：1mg/1ml
英文名： HCFC1R1
别名： HCF 1 beta propeller interacting protein; HCF-1 beta-propeller-interacting protein; HCF1 beta propeller interacting protein; HCFC1R1; Host cell factor C1 regulator 1 (XPO1 dependent); Host cell factor
分子量： 15kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HCFC1R1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核 细胞浆
宿主细胞因子C1调节蛋白1抗体产品介绍：background: PSTPIP1 is a 416 amino acid protein that localizes to both the cytoplasm and the cytoskeleton and contains one SH3 domain and one FCH domain. Expressed at high levels in T cells and spleen and present at lower levels in thymus, lung, placenta and small intestine, PSTPIP1 interacts with CD2AP, BDP1 and c-Abl and is involved in the regulation of the Actin cytoskeleton, possibly functioning as a scaffold protein that may promote Actin polymerization. Defects in the gene encoding PSTPIP1 are the cause of PAPA syndrome (PAPAS), an autosomal dominant disease characterized by recurring inflammatory episodes that affect skin and joint tissue.宿主细胞因子C1调节蛋白1抗体 Multiple isoforms of PSTPIP1 exist due to alternative splicing events. Function: Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus. Subcellular Location: Cytoplasm. Nucleus. Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner. Tissue Specificity: Widely expressed. Gene ID: 54985 Database links: Entrez Gene: 宿主细胞因子C1调节蛋白1抗体535210 Cow Entrez Gene: 54985 Human Entrez Gene: 353502 Mouse SwissProt: Q2M2S6 Cow SwissProt: Q9NWW0 Human SwissProt: Q9CYQ5 Mouse Unigene: 423103 Human Unigene: 728247 Human Unigene: 359030 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
宿主细胞因子C1调节蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：信号转导 生长因子和** 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid