异质核核糖核蛋白A/B抗体
规格：1mg/1ml
英文名： hnRNP A/B
别名： ABBP 1; ABBP-1; ABBP1; APOBEC1 binding protein 1; APOBEC1-binding protein 1; Apolipoprotein B mRNA editing enzyme catalytic polypeptide 1- protein 1; FLJ40338; Heterogeneous nuclear ribonucleoprotein
分子量： 36kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human hnRNP A/
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Guinea Pig,
细胞定位：细胞核 细胞浆
异质核核糖核蛋白A/B抗体产品介绍：background: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. 异质核核糖核蛋白A/B抗体Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] Function: Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site. Subcellular Location: Nucleus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Tissue Specificity: Ubiquitous. Post-translational modifications: Dimethylation at Arg-322 is probably asymmetric. Similarity: Contains 2 RRM (RNA 异质核核糖核蛋白A/B抗体recognition motif) domains. Database links: Entrez Gene: 513410 Cow Entrez Gene: 3182 Human Entrez Gene: 15384 Mouse Entrez Gene: 83498 Rat Omim: 602688 Human SwissProt: Q99729 Human SwissProt: Q99020 Mouse Unigene: 591731 Human Unigene: 715055 Human Unigene: 256875 Mouse Unigene: 280842 Mouse Unigene: 1427 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
异质核核糖核蛋白A/B抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 结合蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid