异质核糖核蛋白M1-M4抗体
规格：1mg/1ml
英文名： hnRNP M1-M4
别名： CEA receptor; CEAR; DKFZp547H118; Heterogeneous nuclear ribonucleoprotein M; Heterogeneous nuclear ribonucleoprotein M4; Heterogenous nuclear ribonucleoprotein M4; hnRNA binding protein M4; hnRNP M; H
分子量： 78kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human hnRNP M1
交叉反应：Human, Mouse, Rat, Dog, Horse,
细胞定位：细胞核
异质核糖核蛋白M1-M4抗体产品介绍：background: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011] Function:异质核糖核蛋白M1-M4抗体 Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. Subcellular Location: Nucleus > nucleolus. Post-translational modifications: Sumoylated. Similarity: Contains 3 RRM (RNA recognition motif) domains. Gene ID: 4670 Database links: Entrez Gene: 4670 Human Entrez Gene: 76936异质核糖核蛋白M1-M4抗体 Mouse Entrez Gene: 116655 Rat Omim: 160994 Human SwissProt: P52272 Human SwissProt: Q9D0E1 Mouse SwissProt: Q62826 Rat Unigene: 465808 Human Unigene: 666214 Human Unigene: 311439 Mouse Unigene: 10156 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
异质核糖核蛋白M1-M4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 染色质和核信号 结合蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid