TOX4蛋白抗体
规格：1mg/1ml
英文名： TOX4
别名： Epidermal Langerhans cell protein LCP1; C14orf92; KIAA0737; LCP1; MIG7; Migration inducing protein 7; TOX 4; TOX high mobility group box family member 4; Tox4; TOX4_HUMAN.
分子量： 66kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TOX4
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Sheep, Cat,
细胞定位：
TOX4蛋白抗体产品介绍：background: TOX high mobility group box family member 4 (TOX4), also known as epidermal Langerhans cell protein 1 (LCP1), is a 621 amino acid protein that localizes to the nucleus. Mapping to chromosome 14q11.2, TOX4 contains one high mobility group (HMG) box DNA-binding domain, corresponding to amino acids 223 to 291 of human TOX4. The HMG box domain is a region of about 80 amino acids with unusual DNA binding preferences. HMG proteins bind DNA without sequence specificity. Furthermore, they bind to distorted or modified DNA and have the property to bend DNA. The presence of the HMG box DNA-binding domain suggests that TOX4 plays a role in transcriptional regulation. Function: Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. {ECO:0000269|PubMed:20516061}. Subunit: Component of the TOX4蛋白抗体PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82 and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R10/PNUTS. {ECO:0000269|PubMed:20516061}. Subcellular Location: Nucleus {ECO:0000305|PubMed:20516061}. Note=Associated TOX4蛋白抗体with chromatin. Similarity: Contains 1 HMG box DNA-binding domain. Gene ID: 9878 Database links: Entrez Gene: 9878 Human Entrez Gene: 515314 Cow Entrez Gene: 475403 Dog Entrez Gene: 268741 Mouse Entrez Gene: 286990 Rat SwissProt: Q0P5K4 Cow SwissProt: O94842 Human SwissProt: Q8BU11 Mouse SwissProt: Q99PM1 Rat Unigene: 555910 Human Unigene: 246237 Mouse Unigene: 22195 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
TOX4蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 结合蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid