SGEF蛋白抗体
规格：1mg/1ml
英文名： SGEF
别名： ARHGEF26; ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26; ARHGQ_HUMAN; CSGEF; DKFZp434D146; HMFN1864; Rho guanine nucleotide exchange factor 26; SH3 domain-containing guanine exchange factor
分子量： 97kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SGEF
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Saccharomyces cerevisiae
细胞定位：
SGEF蛋白抗体产品介绍：background: This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011] Function: Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. SGEF蛋白抗体Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. Subcellular Location: Cell projection > ruffle. Tissue Specificity: Isoform 1 is broadly expressed, with highest levels in liver (at protein level). Certain mRNA species appear to be specifically expressed in prostate and liver. Similarity: Contains 1 DH (DBL-homology) domain. Contains 1 PH domain. Contains 1 SH3 domain. Database links: Entrez Gene:SGEF蛋白抗体 26084 Human Entrez Gene: 622434 Mouse Entrez Gene: 310460 Rat SwissProt: Q96DR7 Human SwissProt: D3YYY8 Mouse SwissProt: D4A1D2 Rat Unigene: 240845 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
SGEF蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid