清道夫受体B1+B2抗体
规格：1mg/1ml
英文名： Scavenger Receptor BI + BII
别名： 85 kDa lysosomal membrane sialoglycoprotein; CD36 and LIMPII Analogous 1; CD36L1; CD36L2; CLA1; HLGP85; LGP85; LIMP II; Lysosome membrane protein II; MGC138242; SCARB1; SCARB2; Scavenger receptor clas
分子量： 82kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Scavenge
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜
清道夫受体B1+B2抗体产品介绍：background: The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011] Function: High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are the alternatively spliced products of a single gene. SR-BII and SR-BI are identical except for the encoded c-terminal cytoplasmic domain. Both SR-BI and SR-BII bind HDL and mediates selective uptake of HDL cholesteryl ester, but with SR-BII having an approximately 4-fold lower efficiency than SR-BI. SR-BI and SR-BII are expressed primarily in liver and non-placental steroidgenic tissues. Although the role of these scavenger receptors is not completely clear, SR-BII mRNA results from the alternative splicing of SR-BI 清道夫受体B1+B2抗体precursor transcripts with both isoforms mediating selective transfer of lipid between HDL and cells. Therefore, the relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells. Subcellular Location: Lysosome; lysosomal membrane; multi-pass membrane protein. Database links: Entrez Gene: 949 Human Entrez Gene: 950 Human Entrez清道夫受体B1+B2抗体 Gene: 12492 Mouse Entrez Gene: 20778 Mouse Entrez Gene: 117106 Rat Entrez Gene: 25073 Rat Omim: 601040 Human Omim: 602257 Human SwissProt: Q14108 Human SwissProt: Q8WTV0 Human SwissProt: O35114 Mouse SwissProt: Q61009 Mouse SwissProt: P27615 Rat SwissProt: P97943 Rat Unigene: 298813 Human Unigene: 349656 Human Unigene: 592984 Human Unigene: 282242 Mouse Unigene: 297964 Mouse Unigene: 399507 Mouse Unigene: 410528 Mouse Unigene: 3957 Rat Unigene: 88169 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
清道夫受体B1+B2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 细胞生物 信号转导 细胞膜受体 新陈代谢
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid