同类型染色单体凝聚蛋白4抗体
规格：1mg/1ml
英文名： SCC4
别名： K0892; KIAA0892; Mau 2; Mau 2L; mau-2; Mau2; SCC4_HUMAN; MAU2L; Scc 4; SCC4; sister chromatid cohesion 4.
分子量： 69kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SCC4
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,
细胞定位：细胞核
同类型染色单体凝聚蛋白4抗体产品介绍：background: Consisting of around 63 million bases with over 1,400 genes, chromosome 19 makes up over 2% of human genomic DNA. Chromosome 19 includes a diversity of interesting genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin superfamily members including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family, and Fc?receptors. Key genes for eye color and hair color also map to chromosome 19. Peutz-Jeghers syndrome, spinocerebellar ataxia type 6, the stroke disorder CADASIL, hypercholesterolemia and insulin-dependent diabetes have been linked to chromosome 19. Translocations with chromosome 19 and chromosome 14 can be seen in some lymphoproliferative disorders and typically involve the proto-oncogene BCL3. Function: Scc4 (Mau2) is the metazoan homologue of Scc4 in S. cerevisiae. 同类型染色单体凝聚蛋白4抗体In yeast, Scc4 binds to Scc2 to form an essential complex that loads cohesion onto chromosomes. Similarly, the Scc4 / Mau2 protein in metazoans plays a significant role in sister chromatid separation and in loading of cohesin onto chromatin. The Scc2-Scc4 complex is tethered to pre-replication complexes through the Cdc7-Drf1 protein kinase DDK. Subunit: Interacts (via N-terminus) with NIPBL to form the cohesion loading complex. Subcellular Location: Nucleus, nucleoplasm. Note=Binds to chromatin from the end of mitosis until prophase. Similarity: Belongs to the同类型染色单体凝聚蛋白4抗体 SCC4/mau-2 family. Contains 4 TPR repeats. Gene ID: 23383 Database links: Entrez Gene: 23383 Human Entrez Gene: 74549 Mouse Omim: 614560 Human SwissProt: Q9Y6X3 Human SwissProt: Q9D2X5 Mouse SwissProt: B4ZIX8 Xenopus laevis Unigene: 654939 Human Unigene: 269061 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
同类型染色单体凝聚蛋白4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 染色质和核信号 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid