DNA切除修复蛋白1抗体
规格：1mg/1ml
英文名： ERCC1
别名： Excision Repair Cross Complementing 1; DNA excision repair protein ERCC-1; COFS4; UV20; DNA excision repair protein ERCC1; ERCC 1; Excision Repair Cross Complementing Rodent Repair Deficiency Compleme
分子量： 36kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ERCC1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow,
细胞定位：细胞核
DNA切除修复蛋白1抗体产品介绍：background: The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may playDNA切除修复蛋白1抗体 a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009] Subunit: Heterodimer composed of ERCC1 and XPF/ERRC4. Subcellular Location: Nucleus. Similarity: Belongs to the ERCC1/RAD10/SWI10 family. Gene ID: 2067 Database links: Entrez Gene: 2067 Human Entrez Gene: 13870 Mouse Entrez Gene: 292673 Rat Omim: 126380 Human SwissProt: P07992 HumanDNA切除修复蛋白1抗体 SwissProt: P07903 Mouse Unigene: 435981 Human Unigene: 280913 Mouse Unigene: 7320 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. ERCC1蛋白是动物内重要的DNA修复基因家族成员之一。在人体内它的低表达往往伴随着基因不稳定性增加,从而产生肿瘤恶性变的发生。ERCC1是损伤DNA核苷酸切除修复中高度保守的切除性核酶。在哺乳动物的核苷酸切除修复中，XPG负责切割DNA损伤区域的3’端，而ERCC1-XPF复合物在5’端打开切口。目前初步的研究表明，癌瘤中的ERCC1蛋白表达程度越低，顺氯氨铂化疗的效果就越好。ERCC1蛋白阳性的患者，非化疗**的预后要好于接受化疗。
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other DNA切除修复蛋白1抗体applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid